Research & Initiatives
The Advanced Bioengineering & Design Lab brings together mechanical engineering, electronics, and life sciences to lead cutting-edge research in future biohealthcare. Our mission is to merge engineering design with advanced biotechnologies to create innovative solutions that improve human life.
Key research areas include high-performance biosensors for early disease detection and real-time health monitoring; organ-on-chip systems that replicate human organ functions for precision medicine and drug screening; 3D bioprinting technologies using cells and hydrogel-based bioinks for regenerative medicine and tissue engineering; and advanced wearable biosensing devices enabling smart, personalized healthcare.
With a strong track record of international publications, patents, and collaborative projects, the lab provides students with hands-on experience in interdisciplinary research, access to state-of-the-art facilities, and opportunities for global collaboration. The Advanced Bioengineering & Design Lab strives to become a leading hub for precision medicine, smart healthcare, and future-oriented biodesign that delivers real-world benefits to humanity.
Lab on a Chip
An innovative 3D in vitro gut model for drug screening is presented using patterned carbon nanofiber (CNF) bundles as flexible, biocompatible villi scaffolds. A microfluidic system induces villi movement, enhancing cell differentiation and permeability. Compared to 2D controls, the 3D gut-chip with fluidic stress shows the highest Papp, highlighting its strong potential for accurate drug testing.
Biosensor
Alzheimer’s disease (AD) arises from insoluble protein accumulation, with CSF biomarkers offering high diagnostic accuracy. We developed a large-area fluorescent biosensor using CNT-upheaved nanofilm and achieved optimized roughness and plasma-enhanced adsorption. The sensor enabled highly sensitive detection of AD biomarkers in artificial and monkey CSF down to 0.1 fM.
Biochip
This study introduces a cost-effective, reproducible microwell fabrication method using pressure-assisted steam technology. The microwells, with tunable mechanical properties and gold coating, enabled stable DNA detection via electric fields. Fluorescence assays with lambda DNA confirmed effective sensing, with the 2.8 mm microwell showing the highest sensitivity and lowest RSD (1.85%). These results demonstrate strong potential for high-throughput DNA biosensing applications.
Tissue Engineering
This study proposes an innovative cell sheet technology using mechanical and electrical stimulation to overcome necrosis in conventional sheets. A microstructured membrane enhances cell bioactivity, accelerates sheet detachment, and promotes angiogenesis and re-epithelialization. Validated in vitro and in vivo, this approach shows strong potential for rapid wound healing in regenerative medicine.